In the context of the 4th industrial revolution, the smart optimization of all the items in a manufacturing process (including concept generation, production and product transaction) is becoming more and more important. The new smart, connected products, along with the massive usage of unstructured information coming from Internet of Things and Big Data, are demanding a whole new technology infrastructure within a company. This Special Issue intends to investigate the latest challenges and opportunities for the ICT field in the context of the 4th Industrial Revolution, across multiple sectors and different industrial applications.